RADIOPHARMACEUTICAL COMPLEXES
Ecuador Patent
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Abstract
The invention provides a method for the formation of a tissue targeted thorium complex, wherein said method comprises; a) forming an octadentate chelator comprising four hydroxypyridinone (HOPO) moieties substituted in the N position with a C1-C3alkyl group, and a coupling portion ending in a carboxylic acid group; b) coupling said octadentate chelator to at least one tissue targeting peptide or protein comprising at least one amine portion by means of at least one amide coupling reagent to thereby generate a tissue targeting chelator; and c) contacting said tissue targeting chelator with an aqueous solution comprising an ion of at least one alpha-emitting thorium isotope. A method of treating a neoplastic or hyperplastic disease comprising the administration of said thorium complex directed to tissue, as well as the corresponding complex and pharmaceutical formulations are provided.
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