PROCESS FOR PREPARING CYCLOHEXANEDIACETIC ACID MONOAMIDE

European Patent Office Patent

PATENT NO 1732899
APP PUB NO EP-1732899-A2
SERIAL NO

05729686

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Abstract

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A new process is described for synthesising cyclohexanediacetic acid monoamide, a key compound in the synthesis of grabapentin precursors. The process of the invention is characterised by reacting cyclohexanone with cynoacetamide and immediately after, with a suitable malonic acid ester. A new intermediate (5-cyano-2,4-dioxo-3-azaspiro[5,5]undecane-1-carboxylic acid ester) is obtained which is convertible, under mild reaction conditions, into cyclohexanediacetic acid monoamide.

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Patent Owner(s)

Patent OwnerAddress
SERICHIM S R LIT33050 TORVISCOSA

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Inventor(s)

Inventor Name Address
DELOGU PIETRO I-33050 TORVISCOSA
DE ROSA SABRINA VIA MESOL 18 33052 CERVIGNANO DEL FRIULI 33052
DANIELI BRUNO 36031 DUEVILLE (VICENZA)
FUGAZZA LORENZA 86077 POZZILLI ISERNIA

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