AAV MEDIATED GENE DELIVERY TO COCHLEAR CELLS

European Patent Office Patent

APP PUB NO EP-1755400-A2
SERIAL NO

05814107

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Abstract

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The present invention is directed to a method of transducing mammalian cochlear cells, more preferably, cochlear hair cells and support cells. The method involves the delivery of adeno-associated virus (AAV) to a target mammalian cochlear cell. The AAV comprises DNA which is exogenous to the AAV and a promoter operatively linked to the DNA. Preferably, the promoter is a cell specific promoter, e.g., hair cell or support cell specific promoter, and the AAV is serotype 1, 2, 6, or a mixture of two or more serotypes. The present invention also relates to compositions comprising modified AAV useful in transducing specific cochlear cells.

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Patent Owner(s)

Patent OwnerAddress
UNIV MONTANAUSMONTANA

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Inventor(s)

Inventor Name Address
LURIE DIANA MISSOULA MT 59803
VONDOERSTEN PETER MISSOULA MT 59808
POULSEN DAVID MISSOULA MT 59803
STONE IDA MISSOULA MT 59803

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