ANTIBODIES SPECIFIC TO PRO-ANGIOGENIC ISOFORMS OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF)

European Patent Office Patent

APP PUB NO EP-2203480-A1
SERIAL NO

08842953

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Abstract

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The present invention provides antibodies, as well as molecules having at least the antigen-binding portion of an antibody, against agonist pro-angiogenic, pro-permeability, vasodilatory isoforms of VEGF. Disclosed antibodies and antibody fragments are characterized by being capable of binding to and neutralizing pro-angiogenic forms of VEGF while not effecting isoforms of VEGF which are anti angiogenic. Methods of production and use in therapy and diagnosis, of such antibodies and antibody fragments are also provided.

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Patent Owner(s)

Patent OwnerAddress
UNIV BRISTOLGBBRISTOL

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Inventor(s)

Inventor Name Address
ZE EVI MENACHEM 52408 RAMAT GAN
BATES DAVID O BISHOPSTON BRISTOL
HARPER STEVEN J TINTERN GWENT
MANGELUS MIRIAM Y 58492 HOLON

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