VARIANTS OF C-TYPE NATRIURETIC PEPTIDE

European Patent Office Patent

APP PUB NO EP-2217620-A2
SERIAL NO

08851395

Stats

Importance

Loading Importance Indicators... loading....

Abstract

See full text

The present invention provides variants of C-type natriuretic peptide (CNP) comprising one or more deletions; additions of and/or substitutions with natural amino acids, unnatural amino acids and/or peptidomimetics (including peptide bond isosteres); amino acid extensions; and/or other chemical moieties such as, e.g., poly(ethylene glycol) and hydrophobic acids. The CNP variants are useful as therapeutic agents for the treatment of diseases responsive to CNP, including but not limited to bone-related disorders such as, e.g., skeletal dysplasias and achondroplasia, and vascular smooth muscle disorders such as, e.g., restenosis and arteriosclerosis.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddress
BIOMARIN PHARM INCUS105 DIGITAL DRIVE NOVATO CA 94949 94949

International Classification(s)

Inventor(s)

Inventor Name Address
KAKKIS EMIL D NOVATO CALIFORNIA 94949
WEI DONG AUSTIN TX TEXAS 78733
WENDT DAN J WALNUT CREEK CA 94598
BLIESATH JOSHUA R ESCONDIDO CALIFORNIA 92029
BELL SEAN SAN RAFAEL CA 94901
AOYAGI-SCHARBER MIKA MILL VALLEY 94941

Cited Art Landscape

Load Citation