Nucleic Acid Chemical Modifications

European Patent Office Patent

APP PUB NO EP-2669290-A1
SERIAL NO

13004187

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Abstract

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The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least on nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting and oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.

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Patent Owner(s)

Patent OwnerAddress
ALNYLAM PHARMACEUTICALS INCUSCAMBRIDGE MA 02142

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Inventor(s)

Inventor Name Address
MANOHARAN MUTHIAH CAMBRIDGE MASSACHUSETTS 02142
RAJEEV KALLANTHOTTATHIL G CAMBRIDGE MA
TAKKELLAPATI SUDHAKAR RAO WALPOLE MA 02081
MATSUDA SHIGEO CAMBRIDGE MASSACHUSETTS 02142
KELIN ALEXANDER V CAMBRIDGE 02142

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