PROCESS FOR PRODUCING L-METHIONINE FROM O-PHOSPHO-L-HOMOSERINE AND METHANETHIOL EMPLOYING A MUTATED CYSTATHIONINE GAMMA-SYNTHASE

European Patent Office Patent

APP PUB NO EP-2912185-A2
SERIAL NO

13792606

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Abstract

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Provided is a method for producing L-methionine in which O-phospho-L-homoserine and methanethiol are enzymatically converted into L-methionine and H3P04. Such a conversion is achieved by an enzyme called O-phospho-L-homoserine (OHPS) dependent methionine synthase. Also described are O-phospho-L-homoserine (OHPS) dependent methionine synthases, i.e. proteins which are able to enzymatically convert O-phospho-L-homoserine and methanethiol into L-methionine and H3PO4 as well as microorganisms which have been genetically modified so as to be able to produce L-methionine from O-phospho-L-homoserine and methanethiol. Furthermore described are methods to screen for enzymes that catalyse the conversion of O-phospho-L-homoserine and methanethiol into L-methionine and H3PO4.

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Patent Owner(s)

Patent OwnerAddress
ADISSEO FRANCE SASFRANTONY

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Inventor(s)

Inventor Name Address
MARLIÉRE PHILIPPE 7500 TOURNAI
MERKAMM MURIEL LES ULIS
THOMAS DOMINIQUE ARGENTEUIL
JAILLARDON KARINE ORSAY
LOUIS DOMINIQUE 91470 FORGES LES BAINS

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