MONOCLONAL ANTIBODIES AGAINST ANTITHROMBIN BETA COMPLEXED WITH HEPARIN

European Patent Office Patent

APP PUB NO EP-2970500-A1
SERIAL NO

14722465

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Abstract

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This patent document relates to antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human antithrombin β complexed with heparin and/or heparin-like structure (ΑΤβΗ). These ΑΤβΗ binding proteins can block the anti-coagulant activity of ΑΤβ to induce coagulation. Therapeutic uses of these antibodies and binders are described herein as are methods of panning and screening specific antibodies.

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Patent Owner(s)

Patent OwnerAddress
BAYER HEALTHCARE LLCUSWHIPPANY NJ 0781-1544

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Inventor(s)

Inventor Name Address
DITTMER FRANK VENNSTR 42 40627 DÜSSELDORF
MURPHY JOHN E CHIRON CORPORATION INTELLECTUAL PROPERTY - R440 P O BOX 8097 EMERYVILLE CA 94662-8097
GRITZAN UWE SCHIRMERSTRASSE 20 50823 KÖLN 50823
HERMISTON TERRY MILL VALLEY CA 94941
STRERATH MICHAEL DÜESSELDORF
JIN YE 1600 AMPHITHEATRE PARKWAY MOUNTAIN VIEW CALIFORNIA 94043 94043
MYLES TIMOTHY SUNNYVALE CA

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