3-CARBAMOYLPHENYL-4-CARBOXAMIDE AND ISOPHTALAMIDE DERIVATIVES AS INHIBITORS OF THE WNT SIGNALLING PATHWAY

European Patent Office Patent

APP PUB NO EP-3259263-A1
SERIAL NO

16704456

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Abstract

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The present invention relates to inhibitors of the Wnt signalling pathways of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative disorder, as a sole agent or in combination with other active ingredients, in which: R1 represents a group selected from: C1-C3-alkoxy-C2-C5-alkyl-, (A), (B), (C), (D), (E), (F), (G) or (H); wherein * indicates the point of attachment to the rest of the molecule; R2 represents a group selected from: (I), (J) or (K); wherein * indicates the point of attachment to the rest of the molecule.

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Patent Owner(s)

Patent OwnerAddress
BAYER PHARMA AGDEBERLIN GERMANY

International Classification(s)

Inventor(s)

Inventor Name Address
THEDE KAI JABLONSKISTR 26 10405 BERLIN
LIENAU PHILIP JAHNSTR 13 10967 BERLIN
MÖNNING URSULA 15569 WOLTERSDORF
HÄGEBARTH ANDREA 10247 BERLIN
LIU NINGSHU LIMONENSTR 28 12203 BERLIN
GOLZ STEFAN SPERLINGSTR 17 45472 MÜLHEIM AN DER RUHR
PUHLER FLORIAN 02142 CAMBRIDGE
ZORN LUDWIG OSIANDERWEG 45A 13509 BERLIN
RICHTER ANJA SCHÜTZENSTR 18 12105 BERLIN
SIEGEL FRANZISKA BERLIN
BENDER ECKHARD GUDRUNSTR 6 WOHNUNG 9 40764 LANGENFELD
SCOTT WILLIAM J GUILFORD CT
BASTING DANIEL DÜSSELDORFER STR 127 51063 KÖLN
MÖWES MANFRED 12163 BERLIN
SCHNEIDER DIRK 51519 ODENTHAL

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