Antibody pairs and kits for immunochemical determination of mannan-binding lectin
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United States of America Patent
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May 1, 2007
Grant Date -
Oct 23, 2003
app pub date -
Jun 12, 2002
filing date -
Apr 18, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Various antibodies with different binding characteristics for MBL A or MBL B bound to mannan or MBL A or MBL B bound to an antibody against MBL are provided. Also provided are methods for selecting antibodies against MBL with different binding characteristics and methods and kits for using these antibodies to measure MBL capable of binding to mannan or oligomerized MBL and abnormal, poorly oligomerized MBL in a sample. The methods and kits are useful in diagnosing increased susceptibility to and exacerbation of infections and autoimmune diseases.
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