Correlation of disease activity with clonal expansions of human papillomavirus 16-specific CD8+ T-cells in patients with severe erosive oral lichen planus

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United States of America Patent

PATENT NO 10018629
SERIAL NO

14910612

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Abstract

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A massive clonal expansion of activated CD8+ T-cells with increased frequency of HPV 16-specific CD8+ T-cells was discovered to be a characteristic of oral lichen planus (OLP), indicating a causal link between HPV infection and the dysimmune process. The invention relates to compositions and methods for the diagnosis and treatment of OLP patients.

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Patent Owner(s)

  • INSTITUTE PASTEUR; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); UNIVERSITE PARIS DIDEROT PARIS 7; ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bachelez, Hervé Paris, FR 1 0
Fazilleau, Nicolas La Salvetat Saint Gilles, FR 3 1
Gougeon, Marie-Lise Antony, FR 18 50
Viguier, Manuelle Paris, FR 2 1

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