Formylpyridine derivative having FGFR4 inhibitory activity, preparation method therefor and use thereof

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United States of America

PATENT NO 11312701
APP PUB NO 20210130323A1
SERIAL NO

16633254

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Abstract

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Formylpyridine derivatives having FGFR4 inhibitory activities, a preparation method therefor and use thereof are described. In particular, the formylpyridine derivatives have a structure of formula (I), and the definition of each substituent in the formula are described in the description and claims. The series of compounds of the formula (I) have very strong inhibitory effects on FGFR4 kinases and very high selectivity, and can be widely used in the preparation of medicaments for treating cancers, particularly prostate cancer, liver cancer, pancreatic cancer, esophageal cancer, stomach cancer, lung cancer, breast cancer, ovarian cancer, colon cancer, skin cancer, neuroglioblastoma or rhabdomyosarcoma, and prospectively will be further developed to become a new generation of FGFR4 inhibitors.

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Patent Owner(s)

  • ABBISKO THERAPEUTICS CO., LTD.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Zhui Pudong New Area Shanghai, CN 19 28
Deng, Haibing Pudong New Area Shanghai, CN 11 6
Xu, Yaochang Pudong New Area Shanghai, CN 18 23
Yang, Fei Pudong New Area Shanghai, CN 219 1069
Yu, Hongping Pudong New Area Shanghai, CN 25 35

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