Systems and method for generation of hyperpolarized materials

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United States of America Patent

PATENT NO 11940510
APP PUB NO 20230152399A1
SERIAL NO

17995232

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Abstract

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A method for preparing an NMR material, comprising generating parahydrogen in gas or liquid form at a first location; transporting the parahydrogen away from the first location; mixing a precursor compound including a metabolite component with a catalyst for hydrogenation; hydrogenating the precursor compound using the parahydrogen; transferring polarization in the precursor compound to a nuclear spin of the metabolite component; cleaving a side arm of the precursor compound in a chemical reaction, with the metabolite molecule being one of the products of the reaction; separating the metabolite molecule from the catalyst for hydrogenation and other products of the reaction; and generating metabolite molecules for use in an MRI scanner by extracting a sample of the metabolite molecule having at least 5% polarization.

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Patent Owner(s)

  • NVISION IMAGING TECHNOLOGIES GMBH; UNIVERSITÄT ULM

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Keim, Michael Neu-Ulm, DE 5 22
Plenio, Martin Ulm, DE 6 41
Schwartz, Ilai New-Ulm, DE 11 8
Tratzmiller, Benedikt Ulm, DE 1 0

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