Metallocorrinoids as biologically compatible carriers of pharmacological agents
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United States of America Patent
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Aug 10, 1999
Grant Date -
N/A
app pub date -
Dec 30, 1997
filing date -
Dec 30, 1997
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Abstract
A purified complex of a metallocorrinoid, such as a vitamin B.sub.12 compound, and a pharmacological agent, such as nitric oxide, that is capable of site-specific delivery of the pharmacological agent in vivo. The pharmacological agent is bound to the metallocorrinoid in a non-donating solvent. The complex is then resuspended in a biocompatible medium and inserted into the recipient. The pharmacological agent then releases in vivo, especially under acidic conditions.
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