CDR-grafted anti-tissue factor antibodies and methods of uses there of
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United States of America Patent
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Jun 9, 2009
Grant Date -
Oct 11, 2007
app pub date -
Nov 1, 2006
filing date -
Jun 7, 1995
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Abstract
The present invention provides CDR-grated antibodies against human tissue factor that retain the high binding affinity of rodent monoclonal antibodies against tissue factor but have reduced immunogenicity. The present humanized antibodies are potent anticoagulants and are thus useful in the treatment and prophylaxis of human thrombotic disease. The invention also provides methods of making the CFR-grafted antibodies and pharmaceutical compositions for the attenuation or prevention of coagulation.
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