Branched molecular scaffolds for linking polymer residues to biologically active moieties
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United States of America Patent
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Jun 15, 2010
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app pub date -
Dec 14, 2004
filing date -
Dec 23, 2003
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Abstract
Branched molecular scaffolds are provided which are capable of linking two polymer residues (derived, for example, from polyethylene glycol) to two, three or four residues derived from biologically active molecules (e.g. from whole antibodies or from functionally active fragments or derivatives thereof), the latter being attached to the scaffold by means of hydrolytically stable linkages.
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