Prolonged preservation of blood platelets
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United States of America Patent
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Apr 24, 2001
Issued Date -
N/A
app pub date -
Feb 13, 1996
filing date -
Oct 19, 1994
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Abstract
This invention provides a method for prolonging the preservation of human blood platelets at reduced temperatures. The method uses an inhibitor system that enables blood platelets to retain their functional integrity during storage. In addition, the inhibitor system prevents the generation of cytokines in the platelet preparation during storage at both 22.degree. C. and 4.degree. C. This is accomplished by interrupting normal platelet function during storage, so as to help keep platelets from activating and losing their shape. Before using the platelets in a transfusion, they are returned to their normal functional level by washing the inhibitor system away from the platelets.
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