Treating tumors with TTFields and an aurora kinase inhibitor

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 11298422
APP PUB NO 20190307781A1
SERIAL NO

16377599

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Abstract

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The viability of cancer cells can be reduced by administering an Aurora kinase inhibitor (e.g., MLN8237 or another Aurora A kinase inhibitor, AZD1152 or another Aurora B kinase inhibitor) to the cancer cells, and applying an alternating electric field with a frequency between 100 and 300 kHz (e.g., 200 kHz) to the cancer cells. Furthermore, cancer (e.g., glioblastoma) in a subject may be treated by administering an Aurora kinase inhibitor to the subject, and applying an alternating electric field with frequency between 100 and 300 kHz (e.g., 200 kHz) to a target region of the subject (e.g., the brain).

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Patent Owner(s)

  • NOVOCURE GMBH

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Giladi, Moshe Moshav Herut, IL 50 932
Krex, Dietmar Dresden, DE 1 33
Shnaiderman, Rosa S Haifa, IL 5 107
Temme, Achim Dresden, DE 4 33

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