Compositions comprising cell-impermeant duramycin derivatives
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United States of America Patent
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Feb 1, 2011
Grant Date -
Jul 29, 2004
app pub date -
Aug 15, 2003
filing date -
Jul 15, 2002
priority date (Note) -
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Abstract
Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are advantageous antibody, immunoconjugate and duramycin-based compositions and combinations that bind and inhibit anionic phospholipids and aminophospholipids, for use in the safe and effective treatment of cancer, viral infections and related diseases.
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