Magnetic bead agglomerator for automated ELISA process
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United States of America Patent
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May 11, 2010
Grant Date -
Aug 26, 2004
app pub date -
Feb 25, 2003
filing date -
Feb 25, 2003
priority date (Note) -
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Abstract
Mixing of a sample containing a suspect bioagent or antigen with 1° recognition molecule coated magnetic beads in the preliminary stage of an enzyme linked immunoassay (“ELISA”) procedure is emulated by first inserting the coated magnetic beads into a non-magnetic confinement region, generating a magnetic field B along the axis of said non-magnetic confinement region to agglomerate the coated magnetic beads into a porous mass; then percolating or otherwise forcing the sample solution through said porous mass; and withdrawing the magnetic field to de-agglomerate said coated magnetic beads. In seeping or otherwise flowing through the magnetic beads the molecules of the sample link to respective magnetic beads that are coated with recognition molecules.
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