T-cell modulatory multimeric polypeptides and methods of use thereof

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United States of America Patent

PATENT NO 11905320
APP PUB NO 20230399372A1
SERIAL NO

18202596

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Abstract

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The present disclosure provides variant immunomodulatory polypeptides, and fusion polypeptides comprising the variant immunomodulatory peptides. The present disclosure provides T-cell modulatory multimeric polypeptides, and compositions comprising same, where the T-cell modulatory multimeric polypeptides comprise a variant immunomodulatory polypeptide of the present disclosure. The present disclosure provides nucleic acids comprising nucleotide sequences encoding the T-cell modulatory multimeric polypeptides, and host cells comprising the nucleic acids. The present disclosure provides methods of modulating the activity of a T cell; the methods comprise contacting the T cell with a T-cell modulatory multimeric polypeptide of the present disclosure.

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Patent Owner(s)

  • CUE BIOPHARMA, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chaparro, Rodolfo J Cambridge, US 64 190
Seidel,, III Ronald D Boston, US 80 273

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