Nanocrystals, compositions, and methods that aid particle transport in mucus

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United States of America Patent

PATENT NO 10736854
APP PUB NO 20180256508A1
SERIAL NO

15976736

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Abstract

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Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

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Patent Owner(s)

  • THE JOHNS HOPKINS UNIVERSITY

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bourassa, James Somerville, US 28 241
Chen, Hongming Belmont, US 71 1311
Enlow, Elizabeth M Waltham, US 29 318
Ensign, Laura M Towson, US 12 169
Gardner, Colin R Concord, US 27 611
Hanes, Justin Baltimore, US 99 3261
Lai, Samuel K Carrboro, US 29 731
Popov, Alexey Waltham, US 35 424
Yang, Ming Towson, US 656 3814
Yu, Tao Baltimore, US 249 2024

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