Therapy of tumors and infectious agents deficient in methylthioadenosine phosphorylase
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United States of America Patent
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Aug 5, 2014
Grant Date -
Apr 19, 2012
app pub date -
Aug 15, 2008
filing date -
Aug 29, 2007
priority date (Note) -
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Abstract
Methods for treating diseases in humans and vertebrate animals are provided using competitive antagonists of cellular metabolites combined with a protective agent for protecting host cells from toxic effects of the drugs. Also provided are kits comprising competitive antagonists and suitable protective agents. In addition, screening methods for identifying competitive antagonists, protective agents and potentiating agents, for use according to the methods of the invention, are provided.
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