Antiviral methods using human rhinovirus receptor (ICAM-1)
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United States of America Patent
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Feb 4, 2003
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app pub date -
Sep 30, 1994
filing date -
Sep 1, 1988
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Abstract
A method for substantially inhibiting initiation or spread of infection by rhinovirus or Coxsackie A virus of host cells expressing the major human rhinovirus receptor (ICAM-1), comprising the step of contacting the virus with a soluble polypeptide comprising the HRV binding site in domains I and II of ICAM-1; which polypeptide is capable of binding to the virus and reducing infectivity thereof; the contact being under conditions which permit the virus to bind to the polypeptide.
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