Interleukin-21 mutein/ anti-PD-1 antibody conjugates

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United States of America Patent

PATENT NO 11541103
APP PUB NO 20190046611A1
SERIAL NO

16054035

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Abstract

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Provided herein are IL-21 muteins and fusion proteins comprising the same for use in methods of treating a disease. Related conjugates, nucleic acids, vectors, host cells, pharmaceutical compositions and kits are also provided herein. Methods of making the IL-21 muteins and fusion proteins comprising the same, as well as methods of treating a subject in need thereof, are provided by the present disclosure. Further provided are PD-1 antigen-binding proteins.

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Patent Owner(s)

Patent OwnerAddress
AMGEN INCONE AMGEN CENTER DRIVE THOUSAND OAKS CA 91320-1799

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Agrawal, Neeraj Jagdish Newbury Park, US 21 28
Ali, Khaled M K Z Millbrae, US 2 0
Bates, Darren Thousand Oaks, US 6 22
Foltz, Ian Thousand Oaks, US 69 988
Kannan, Gunasekaran Thousand Oaks, US 54 966
Mock, Marissa Thousand Oaks, US 10 49
Takenaka, Shunsuke Thousand Oaks, US 5 15
Wang, Zhulun Thousand Oaks, US 39 348

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