Thioalkanoyl-carnitines, process for their preparation and mucolytic pharmaceutical compositions containing same
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
May 21, 1985
Grant Date -
N/A
app pub date -
Oct 22, 1982
filing date -
Dec 3, 1981
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Thioalkanoyl-carnitines of general formula (I) ##STR1## wherein R is a straight alkylene radical having from 2 to 6 carbon atoms, or is a branched alkylene radical having from 3-6 carbon atoms, or is a branched alkylene radical having from 3-6 carbon atoms, R.sub.1 is a straight or branched lower alkyl radical having from 1 to 4 carbon atoms, and X.sup.- is a halogen anion are prepared by reacting a thio-acid (II) of general formula R.sub.1 COSH (a) if in (I) the thioalkanoyl radical R.sub.1 COS-- is in terminal position, with a compound of general formula (III) ##STR2## wherein n is an integer comprised between 0 and 4 or (b) if in (I) the thioalkanoyl radical R.sub.1 COS-- is not in terminal position, with a compound of general formula (IV) ##STR3## wherein m and m.sup.1 are integers comprised between 0 and 3, and R.sub.2 is a lower alkyl radical having from 1 to 4 carbon atoms. The pharmaceutical compositions containing the thioalkanoyl-carnitines (I) possess mucolytic and antitussive activity.
First Claim
Family
International Classification(s)
- [Classification Symbol]
- [Patents Count]
Cited Art Landscape
Patent Citation Ranking
Advertisement
Advertisement
Advertisement
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully