Process for the preparation of optically active 2-[6-(substituted alkyl)-1,3-dioxan-4-yl]acetic acid derivatives
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United States of America Patent
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Apr 17, 2007
Grant Date -
Jul 7, 2005
app pub date -
Aug 13, 2002
filing date -
Dec 20, 2001
priority date (Note) -
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Abstract
The present invention relates to new process for preparing as a key chiral intermediate compound of formula (I) obtained from an epoxy-.beta.-hydroxy carboxylic acid ester of formula (II) prepared from epoxide compound of formula (III), in which said compound of formula (I) is useful for preparing the therapeutic agent for hyperlipidemia, such as Astrovastatin and Fluvastatin. Wherein R.sub.1 denotes a hydrogen atom, alkyl, aryl or alkylaryl, R.sub.2 and R.sub.3 which can be identical or different, are a lower alkyl or phenyl and are capable of forming a six-membered ring, R.sub.4 stands for hydroxy, amino, alkylamino, azido, cyano, halogeno, aryloxy, alkyloxy, arylalkyloxy, alkyl, alkenyl, aryl, or aminomethyl, etc.
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