Preparation of drug particles using evaporation precipitation into aqueous solutions
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United States of America Patent
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Jun 29, 2004
Grant Date -
Jun 27, 2002
app pub date -
Mar 14, 2001
filing date -
Nov 3, 2000
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A method for preparing poorly water soluble drug particles is disclosed. The method comprises dissolving a drug in at least one organic solvent to form a drug/organic mixture, spraying the drug/organic mixture into an aqueous solution, and concurrently evaporating the organic solvent in the presence of the aqueous solution to form an aqueous dispersion of the drug particles. The resulting drug particles are in the nanometer to micrometer size range and show enhanced dissolution rates and reduced crystallinity when compared to the unprocessed drug.
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