Attenuated chimeric flavivirus bearing attenuated japanese encephalitis virus gene as backbone

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United States of America Patent

PATENT NO 8492532
APP PUB NO 20090104702A1
SERIAL NO

12292518

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Abstract

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A nucleic acid molecule containing nucleotide sequences that encode the capsid protein, pre-membrane protein and non-structural protein of Japanese encephalitis virus, and a nucleotide sequence that encodes the envelop protein of a second flavivirus, wherein the nucleotide sequence(s) that encode(s) the pre-membrane protein and/or non-structural protein of Japanese encephalitis virus contain(s) nucleotide mutations that produce one or more amino acid mutations that attenuate the virus.

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Patent Owner(s)

  • OSAKA UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fuke, Isao Kanonji, JP 10 58
Goda, Hideo Kanonji, JP 3 10
Ishibashi, Masahide Kanonji, JP 6 29
Ishikawa, Toyokazu Kanonji, JP 6 9
Miyake, Shinichi Kanonji, JP 47 580
Morita, Kouichi Nagasaki, JP 69 682
Nabeshima, Takeshi Nagasaki, JP 2 1
Onishi, Toshiyuki Kanonji, JP 39 410
Takahashi, Michiaki Suita, JP 23 86

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