Disulfide conjugated cell toxins and methods of making and using them

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United States of America Patent

PATENT NO 6881718
SERIAL NO

10110934

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention pertains to the discovery of novel disulfide linked cell toxins which can ablate NK-1 receptor expressing cells. These toxins are used as pharmaceutical compositions for the ablation of NK1 receptor expressing cells and comprise a substance P (SP)-Pseudomonas exotoxin disulfide linked conjugate. The invention also includes methods of making and using these toxins and pharmaceutical compositions.

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Patent Owner(s)

  • THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
FitzGerald, David J Rockville, MD 55 810
Iadarola, Michael J Washington, DC 12 85

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