Anti-MET antibodies, bispecific antigen binding molecules that bind MET, and methods of use thereof

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United States of America Patent

PATENT NO 11142578
APP PUB NO 20180134794A1
SERIAL NO

15814095

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Abstract

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Provided herein are antibodies and bispecific antigen-binding molecules that bind MET and methods of use thereof. The bispecific antigen-binding molecules comprise a first and a second antigen-binding domain, wherein the first and second antigen-binding domains bind to two different (preferably non-overlapping) epitopes of the extracellular domain of human MET. The bispecific antigen-binding molecules are capable of blocking the interaction between human MET and its ligand HGF. The bispecific antigen-binding molecules can exhibit minimal or no MET agonist activity, e.g., as compared to monovalent antigen-binding molecules that comprise only one of the antigen-binding domains of the bispecific molecule, which tend to exert unwanted MET agonist activity. Also included are antibody-drug conjugates (ADCs) comprising the antibodies or bispecific antigen-binding molecules provided herein linked to a cytotoxic agent, radionuclide, or other moiety, as well as methods of treating cancer in a subject by administering to the subject a bispecific antigen-binding molecule or an ADC thereof.

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Patent Owner(s)

  • REGENERON PHARMACEUTICALS, INC.

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Babb, Robert River Edge, US 42 274
Chen, Gang Yorktown Heights, US 887 7724
Daly, Christopher New York, US 43 391
DaSilva, John Somers, US 6 322
MacDonald, Douglas New York, US 55 1413
Nittoli, Thomas Pearl River, US 50 208

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