Methods for producing ribose-1-phosphoric acid and ribavirin
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United States of America Patent
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Nov 6, 1990
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N/A
app pub date -
Sep 15, 1989
filing date -
Jan 19, 1987
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Expired
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Abstract
The present invention relates to methods for producing ribavirin utilizing microorganisms and a method for producing ribose-1-phosphoric acid which is a precursor of ribavirin. The methods involve contacting certain microorganisms with orotidine, orotidic acid, or salts thereof, and inorganic phosphoric acid or a salt thereof (to produce ribose-1-phosphoric acid), and further with 1,2,4-triazole-3-carboxamide or a salt thereof (to produce ribavirin) in an aqueous solvent.
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