Anti-TREM-1 antibodies and uses thereof

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United States of America

PATENT NO 11919954
SERIAL NO

17472302

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more FcγRs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.

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Patent Owner(s)

  • BRISTOL MYERS SQUIBB COMPANY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Carl, Stephen Michael Howell, US 5 1
Chen, Guodong East Brunswick, US 92 286
Gosselin, Michael L Boston, US 16 317
Holmes, Derek A Lawrenceville, US 4 1
Huang, Richard Yu-Cheng Bridgewater, US 7 1
Madia, Priyanka Apurva Franklin Park, US 6 4
Pashine, Achal Mahwah, US 6 20
Yamniuk, Aaron P Lawrenceville, US 32 185

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