Negatively charged self-assembling supported lipid bilayer on mesoporous silica nanoparticles, method of synthesis and use as a nanovector

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United States of America

PATENT NO 11213487
APP PUB NO 20180207096A1
SERIAL NO

15746357

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Abstract

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A method for manufacturing a negatively charged supported lipid bilayer. The method comprises the steps of preparing a formulation comprising at least three lipids (1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS), cholesterol and at least one lipid different from DOPS and cholesterol) dissolved in a first solvent, of evaporating the first solvent, of adding an aqueous formulation of mesoporous silica nanoparticles, of performing an ultra-sonication and of performing a centrifugation. The method is remarkable in that the number of equivalents of cholesterol relative to one equivalent of DOPS is comprised between 2.30 and 2.70. Additionally, negatively charged supported lipid bilayer on a mesoporous silica nanoparticle comprising cholesterol, 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS) and at least one lipid different from DOPS and cholesterol.

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Patent Owner(s)

  • LUXEMBOURG INSTITUTE OF SCIENCE & TECHNOLOGY (LIST)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Corne, Gaelle Audun-le-Tiche, FR 3 0
Lenoble, Damien Wellin, BE 39 142
Thomann, Jean-Sebastien Gorcy, FR 4 0

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