Nano-layered dual hydroxide-biological factor combined system for promoting nerve regeneration to repair spinal cord injury

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United States of America Patent

PATENT NO 11357888
APP PUB NO 20210154362A1
SERIAL NO

16625808

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Abstract

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Disclosed is a nano-layered dual hydroxide-biological factor combined system for promoting nerve regeneration to repair a spinal cord injury. The preparation method therefor comprises: 1) synthesizing a nano-layered dual hydroxide CL1; and 2) co-incubating 10 mg CL1 and 200-2000 ng of biological factors NT3, VEGF or bFGF in a low-speed shaker at 4° C. for 2 hours using an ion exchange method, centrifuging same and then obtaining the precipitate. Experiments on transection and resorption spinal cord injury models show that this combined system has a significant recovery effect on the behavior of model mice, can reconstruct the neural circuit of a damaged area over time and achieves an ideal repair effect with regard to a spinal cord injury.

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Patent Owner(s)

  • SHANGHAI TONGJI HOSPITAL

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cheng, Liming Shanghai, CN 8 21
Wang, Shilong Shanghai, CN 19 13
Zhu, Rongrong Shanghai, CN 6 1

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