Use of enzyme inhibitors of aminopeptidase N and/or dipeptidylpeptidase IV
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United States of America Patent
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Mar 23, 2010
Grant Date -
Feb 23, 2006
app pub date -
Mar 7, 2003
filing date -
Mar 15, 2002
priority date (Note) -
Expired
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Abstract
The invention relates to a process for the-inhibition of the DNA synthesis necessary for the proliferation of human sebaceous cells (sebocytes) by the isolated or joint effect of inhibitors of alanyl aminopeptidase (APN) and dipetidyl peptidase IV (DP IV) expressed by these cells. The DNA synthesis (proliferation) of human sebaceous cells is inhibited by the administration of the inhibitors of APN and/or of DP IV depending on the dose. Our invention shows that, for a therapy and for a prevention of dermatological diseases with sebaceous hyperproliferation and modified conditions of differentiation, the application of inhibitors of the above-mentioned enzymes and of corresponding pharmaceutical preparations and dosage forms thereof is suitable.
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