Process for enhancing the solubility of poorly soluble drugs
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United States of America Patent
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Oct 27, 2009
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N/A
app pub date -
Feb 25, 2008
filing date -
Mar 7, 2007
priority date (Note) -
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Abstract
The solubility/dissolution rate of a poorly soluble drug is enhanced by a process that utilizes a twin-screw extruder containing (i) a feed zone containing a first liquid and powder feed stations; (ii) a grinding/mixing zone containing a second liquid feed port located at an upstream portion of such zone; (iii) a granulation zone containing a second powder feed station located at an upstream portion of such zone and a third liquid feed port located at a downstream portion of such zone; and (iv) a wet milling zone.
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