Synthetic peptides immunoreactive with hepatitis A virus antibodies

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United States of America Patent

PATENT NO 7223535
SERIAL NO

10738443

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Abstract

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Synthetic peptides immunoreactive with hepatitis A virus (HAV) antibodies are provided. The peptides are useful as laboratory reagents to detect or quantify HAV antibodies in biological samples in clinical or research-based assays and for inducing an immune response to HAV when administered to a human or animal. The peptides contain antigenic epitopes, modified antigenic epitopes or combinations of epitopes of the major structural capsid polypeptides or non-structural polypeptides of HAV and contain one or more molecules of the amino acid glutamine (Q) at the carboxyl end of the peptide, which enhances immunoreactivity and immunogenicity, particularly IgM antibody reactivity.

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Patent Owner(s)

Patent OwnerAddress
HEALTH AND HUMAN SERVICES GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF THEOFFICE OF TECHNOLOGY TRANSFER 6011 EXECUTIVE BLVD OFFICE OF TECHNOLOGY TRANSFER 6011 EXECUTIVE BLVD ROCKVILLE MD 20852

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fields, Howard A Marietta, GA 12 49
Khudyakov, Yury E Duluth, GA 9 25

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