Combinatorial selection of oligonucleotide aptamers
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United States of America Patent
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Feb 20, 2007
Grant Date -
Feb 6, 2003
app pub date -
Apr 11, 2002
filing date -
Oct 26, 1998
priority date (Note) -
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Abstract
A random combinatorial selection method is disclosed for the construction of oligonucleotide aptamers in which nuclease resistance is conferred by the inclusion of modified nucleotides. The modified nucleotides are incorporated during PCR amplification to form achiral modified oligonucleotides. Thio-substituted aptamers are provided that bind tightly to the nuclear factor for human IL6 (NF-IL6).
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