Peptidyl heterocyclic ketones useful as tryptase inhibitors

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United States of America Patent

PATENT NO 6469036
SERIAL NO

09482802

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Abstract

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The present invention relates to a series of peptidyl heterocyclic ketones which are inflammatory cell serine protease inhibitors and their compositions and methods for the prevention and treatment of a variety of immunomediated inflammatory disorders. More particularly, these compounds are potent and selective inhibitors of tryptase and are therefore effective for the prevention and treatment of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis.

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Patent Owner(s)

Patent OwnerAddress
ORTHO-MCNEIL PHARMACEUTICAL INCRARITAN NJ

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Costanzo, Michael J Ivyland, PA 22 292
Maryanoff, Bruce E Forest Grove, PA 104 902
Yabut, Stephen C North Wales, PA 8 28

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