Process for purifying thienamycin
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United States of America Patent
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Apr 15, 1980
Grant Date -
N/A
app pub date -
Mar 13, 1978
filing date -
Mar 13, 1978
priority date (Note) -
Expired
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Abstract
Fermentation broths or impure solutions containing thienamycin, a substance having antibiotic activity against gram-negative and gram-positive microorganisms, are purified using a sequence of ion exchange resins, starting with an anion exchange resin of the polystyrene-trimethylammonium type in the HCO.sub.3 -cycle, and ending with absorption on and elution from a polymeric cross-linked polystyrene-type resin adsorbent. Variations in the intermediate steps, e.g. different resins and eluates are possible and are illustrated within.
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