Peptide epitopes recognized by disease promoting CD4+ T lymphocytes
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United States of America Patent
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Aug 5, 2008
Grant Date -
Jun 21, 2007
app pub date -
Feb 2, 2007
filing date -
Apr 21, 1999
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Abstract
The invention provides methods for identifying peptide epitopes that activate CD4+ T cells involved in the pathogenesis of diseases, e.g., autoimmune diseases, susceptibility to which is determined by expression of particular class II MHC genes. The invention includes peptides derived from the IA-2 polypeptide by such a method, altered peptide ligands, and methods of therapy involving the use of altered peptide ligands.
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