CL-1577-B.sub.4 compound, its production and use
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United States of America Patent
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Apr 28, 1987
Issued Date -
N/A
app pub date -
Dec 4, 1985
filing date -
Mar 15, 1985
priority date (Note) -
Expired
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Abstract
CL-1577-B.sub.4 compound is derived by the solvolysis under anhydrous conditions of either CL-1577A compound of CL-1577B compound, obtained from the fermentative action of a purified strain of Actinomycete designated ATCC 39363 under aerobic conditions. CL-1577-B.sub.4 compound is a potent antimicrobial agent, possessing activity against a number of gram-positive and gram-negative bacteria, yeasts, and fungi. In addition, the compound exhibits in vivo activity against the P388 murine leukemia cell line and in vitro activity against the L1210 murine leukemia cell line. A method of making the compound as well as pharmaceutical compositions and methods for their use are also disclosed.
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