Integrated protein affinity capture centrifugation device
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United States of America Patent
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Apr 6, 2004
Grant Date -
Jun 19, 2003
app pub date -
Dec 18, 2001
filing date -
Dec 18, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A method and apparatus are described for screening a proteome. The method and apparatus include an array of affinity elements, such that a proteome is directed through the array and those components that specifically bind to the affinity elements of the array are eluted in a suitable eluent by means of centrifugation. Suitable eluents can include a proteome component, a chemical library component or an affinity element. This method and apparatus can be used for several purposes, including screening for bio-active compounds, determining physiological targets of known drugs, determining specificity of compound interactions with physiological targets, and for quantitative protein analyses.
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