3-Quinolinecarbonitrile protein kinase inhibitors
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United States of America Patent
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Nov 11, 2008
Grant Date -
Aug 25, 2005
app pub date -
Feb 16, 2005
filing date -
Feb 20, 2004
priority date (Note) -
Expired
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Abstract
This invention provides a compound of Formula 1 ##STR00001## where Ar, X, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are defined herein, or a pharmaceutically acceptable salt thereof useful in the prevention or inhibition of diseases associated with the Ras/Raf/MEK signaling cascade in a mammal, such as neoplasms, strokes, osteoporosis, cancer, rheumatoid arthritis, inflammatory disease, polycystic kidney disease, and colonic polyps, and methods of making the compounds of formula 1 and intermediates.
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