Therapeutic use of interleukin-2 mutants
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United States of America Patent
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Apr 7, 2009
Grant Date -
Dec 28, 2006
app pub date -
Mar 29, 2005
filing date -
Aug 13, 2001
priority date (Note) -
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Abstract
Interleukin-2 (IL-2) mutants having reduced toxicity, which include full-length IL-2, truncated forms of IL-2 and forms of IL-2 that are linked to another molecule are disclosed herein. Particular substitutions within IL-2, particularly within the permeability enhancing peptide region of IL-2 achieve substantial reduction of vasopermeability activity as compared to a wildytpe form of the mutant IL-2 while retaining many of the immune activating properties of IL-2. Invention IL-2 mutants can be used to stimulate the immune system of an animal and may be used in the treatment of various disorders and conditions.
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