Tumor necrosis factor superfamily and TNF-like ligand muteins and methods of preparing

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United States of America Patent

PATENT NO 11111284
APP PUB NO 20170260245A1
SERIAL NO

15504968

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention features homo-multimers, e.g., homo-trimers, of TNFSF or TNF-like ligand muteins in which each TNFSF ligand or TNF-like ligand mutein monomer contains at least one cysteine residue substitution or insertion that promotes the formation of a disulfide bond with a cysteine residue on a neighboring TNFSF or TNF-like ligand mutein monomer. The invention features methods of producing such TNFSF and TNF-like ligand muteins, pharmaceutical compositions containing such muteins, and methods of using such muteins in cancer immunotherapy, in treating autoimmune and neurological diseases, and in reducing or eliminating the complications and risks of rejection in organ transplantation or tissue or organ repair or regeneration.

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Patent Owner(s)

  • THE GENERAL HOSPITAL CORPORATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Faustman, Denise L Boston, US 46 546
Vanamee, Eva Boston, US 2 1

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