Medicinal drug with activity against gram positive bacteria, mycobacteria and fungi

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United States of America Patent

PATENT NO 9433623
APP PUB NO 20160000786A1
SERIAL NO

14427915

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Abstract

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The invention relates to chemistry and pharmacology, in particular to synthetic biologically active substances of the pyrimidine series that have antimicrobial activity, and to the method of synthesis thereof. According to the invention there is provided a new substance with activity against gram positive bacteria, mycobacteria and fungi characterized in that it constitutes 5-(2-hydroxybenzylidene) derivatives of the pyrimidinone series with the general formula 1 where XI, X3 are selected from the group containing: H, halogen; N02; X2, X4 are selected from the group containing: H, halogen: Z is selected from the group containing: 0, NNH2, NOH, pei†iydropyrimidine-5-ytidene-2,4,6-trione, perhydropyrimidine-5-ylidene-2,4,6-trione, substituted at the nitrogen atom With alkyl, aryl or aralkyl group; Y is selected from the group containing: H, Na, Li, K.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Levina, Elizabeth New York, US 2 0

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