Screening for agents effective in decreasing abnormal macrophages associated with amyotrophic lateral sclerosis
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United States of America Patent
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Apr 3, 2007
Grant Date -
Sep 18, 2003
app pub date -
Nov 18, 2002
filing date -
Nov 16, 2001
priority date (Note) -
Expired
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Abstract
The invention provides methods of monitoring amyotrophic lateral sclerosis (ALS) disease development or progression and monitoring an ALS therapy by determining the level of HLA-DR expression by CD14+ monocytes and/or the percentage of CD16+ cells in the population of CD14+ cells and/or the number of CD14+/CD16+ cells in peripheral blood of an individual with ALS. The invention is also directed to methods for decreasing the number of circulating CD14+ monocytes and/or the population of CD14+/CD16+ cells and/or the number of CD14+/CD16+ cells in an individual with ALS. The invention is also directed to methods of screening for agents which decrease the population of CD14+ monocytes with elevated HLA-DR expression and/or the population of CD14+/CD16+ cells and/or the number of CD14+/CD16+ cells in an individual with ALS.
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