Formulation of boronic acid compounds
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United States of America Patent
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Mar 30, 2004
Grant Date -
Nov 14, 2002
app pub date -
Jan 25, 2002
filing date -
Jan 25, 2001
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Abstract
The present invention provides stable compounds prepared from boronic acid and lyophilized compounds thereof of the formula (1): ##STR1## in which Z.sup.1 and Z.sup.2 are moieties derived from sugar. The invention also provides methods for preparing such compounds. Lyophilizing a mixture comprising a boronic acid compound and a moiety derived from sugar produces a stable composition that readily releases the boronic acid compound upon reconstitution in aqueous media.
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